Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya

Fibroblasts play a role in the wound healing process. The active compound content of Spirulina sp. has fibroblastic activity. use extracts from S. platensis can To analyze effectiveness extract on number fibroblasts rats that were incised their skin. This study used randomized post test only control group design. Forty-eight male Wistar skin and infected with S.aureus divided into 4 groups, namely given S.platensis at dose 500 mg/kgBW/day, 750 negative was saline solution positive diclofenac 20 mg/kgBW orally. counted histopathological examination tissue 7th 14th days covering 5 visual fields. Data analysis carried out one way ANOVA continued LSD Post Hoc Test. mean day mg/kgBW/day group, 13.33 ± 3.615; 117.42±3.980; 9.58±2.417; 4.00 1.761 p 0.001. 16.17 3.251; 19.67±1.633; 12.17±2.137; 8.33 2.317 hoc found 7 significantly increased mg/kgBB/day compared to groups. While mg/kg/day, higher than groups after 14 treatment.Administration doses mg/kg/day incision wounds rats.